Burkholderia pseudomallei K96243, BPSS1527 (bapB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1527
Name
bapB
Replicon chromosome 2
Genomic location 2079819 - 2080100 (- strand)
CommentThis gene is part of the type III secretion system T3SS-3 (bsa) gene locus. Transcription of bopE and secretion of the BopE protein were increased in the bapB mutant, indicating that BapB is likely to play a role in modulating bopE expression (PMID:26624293).

Cross-References

RefSeq YP_111533.1
GI 53722548
Entrez 3097128
GI 53722548
INSDC CAH39000.1
NCBI Locus Tag BPSS1527
RefSeq YP_111533.1,GeneID
UniParc UPI000043BD19
UniProtKB Acc Q63K39
UniProtKB ID Q63K39_BURPS
UniRef100 UniRef100_A0A069BDZ9
UniRef50 UniRef50_A3MCH4
UniRef90 UniRef90_A3MCH4

Product

Feature Type CDS
Coding Frame 1
Product Name
BapB (T3SS-3)
Product Name Confidence: Class 1
Synonyms acyl carrier protein
Evidence for Translation
Charge (pH 7) -7.77
Kyte-Doolittle Hydrophobicity Value 0.310
Molecular Weight (kDa) 9588.8
Isoelectric Point (pI) 4.07

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 122 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019827 (317 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1527
Search term: bapB
Search term: BapB (T3SS-3)

Human Homologs

References

The Burkholderia pseudomallei Proteins BapA and BapC Are Secreted TTSS3 Effectors and BapB Levels Modulate Expression of BopE.
Treerat P, Alwis P, D'Cruze T, Cullinane M, Vadivelu J, Devenish RJ, Prescott M, Adler B, Boyce JD
PLoS One 2015;10(12):e0143916
PubMed ID: 26624293
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152