Burkholderia pseudomallei K96243, BPSS1526 (bapC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1526
Name
bapC
Replicon chromosome 2
Genomic location 2079259 - 2079822 (- strand)
CommentThis gene is part of the type III secretion system T3SS-3 (bsa) gene locus.

Cross-References

RefSeq YP_111532.1
GI 53722547
Entrez 3097079
GI 53722547
INSDC CAH38999.1
NCBI Locus Tag BPSS1526
RefSeq YP_111532.1,GeneID
UniParc UPI000043BD18
UniProtKB Acc Q63K40
UniProtKB ID Q63K40_BURPS
UniRef100 UniRef100_A0A095PMR4
UniRef50 UniRef50_Q3JL29
UniRef90 UniRef90_Q3JL29

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system effector protein BapC (T3SS-3)
Product Name Confidence: Class 1
Synonyms invasion protein
Evidence for Translation
Charge (pH 7) 9.40
Kyte-Doolittle Hydrophobicity Value -0.239
Molecular Weight (kDa) 20199.5
Isoelectric Point (pI) 10.32

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Extracellular Class 1
direct assay evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 81 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019826 (317 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1526
Search term: bapC

Human Homologs

References

The Burkholderia pseudomallei Proteins BapA and BapC Are Secreted TTSS3 Effectors and BapB Levels Modulate Expression of BopE.
Treerat P, Alwis P, D'Cruze T, Cullinane M, Vadivelu J, Devenish RJ, Prescott M, Adler B, Boyce JD
PLoS One 2015;10(12):e0143916
PubMed ID: 26624293
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152