Burkholderia pseudomallei K96243, BPSS1520 (bprC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
Locus Tag
BPSS1520
Name
bprC
Replicon chromosome 2
Genomic location 2072125 - 2073186 (- strand)
CommentThis gene is part of the type III secretion system T3SS-3 (bsa) gene locus. In a bprC mutant, the expression of virA and virG was downregulated to 30% and 42%, respectively, whereas tssA expression was decreased to 4% of wild-type level (PMID:20345664).

Cross-References

RefSeq YP_111526.1
GI 53722541
Entrez 3095464
GI 53722541
NCBI Locus Tag BPSS1520
RefSeq YP_111526.1,GeneID
UniProtKB Acc Q63K46
UniProtKB ID Q63K46_BURPS

Product

Feature Type CDS
Coding Frame 1
Product Name
regulator of type VI secretion system-1 BprC
Product Name Confidence: Class 1
Synonyms AraC family transcriptional regulator
Evidence for Translation
Charge (pH 7) 18.85
Kyte-Doolittle Hydrophobicity Value -0.229
Molecular Weight (kDa) 38910.0
Isoelectric Point (pI) 10.57

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 177 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019818 (317 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1520
Search term: bprC

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW(1), Gan YH.
Trends Microbiol. 2010 Dec;18(12):561-8.
PubMed ID: 20951592
Identification of a regulatory cascade controlling Type III Secretion System 3 gene expression in Burkholderia pseudomallei.
Sun GW(1), Chen Y, Liu Y, Tan GY, Ong C, Tan P, Gan YH.
Mol Microbiol. 2010 May;76(3):677-89.
PubMed ID: 20345664
PubMed ID: 21670170
Characterization of BPSS1521 (bprD), a regulator of Burkholderia pseudomallei virulence gene expression in the mouse model.
Chirakul S(1), Bartpho T(2), Wongsurawat T(3), Taweechaisupapong S(4), Karoonutaisiri N(3), Talaat AM(5), Wongratanacheewin S(6), Ernst RK(7), Sermswan RW(1).
PLoS One. 2014 Aug 11;9(8):e104313.
PubMed ID: 25111708
PubMed ID: 28664152