Burkholderia pseudomallei K96243, BPSS1508 (tssJ-5)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
Locus Tag
BPSS1508
Name
tssJ-5
Replicon chromosome 2
Genomic location 2057929 - 2058606 (+ strand)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-5 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-1 cluster later (PMID:21670170, PMID:22007185) and by the B. mallei literature (PMID:22892068, PMID:17555434).

Cross-References

RefSeq YP_111515.1
GI 53722530
Entrez 3096370
GI 53722530
NCBI Locus Tag BPSS1508
RefSeq YP_111515.1,GeneID
UniProtKB Acc Q63K57
UniProtKB ID Q63K57_BURPS

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssJ-5
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 6.44
Kyte-Doolittle Hydrophobicity Value -0.288
Molecular Weight (kDa) 24218.1
Isoelectric Point (pI) 9.99

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database VFDB : VF0429
Category T6SS-1
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 14 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019350 (320 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1508
Search term: tssJ-5

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS.
Microbiology. 2007 Aug;153(Pt 8):2689-99.
PubMed ID: 17660433
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA(1), Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D.
Mol Microbiol. 2007 Jun;64(6):1466-85.
PubMed ID: 17555434