Strain |
Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest |
Locus Tag |
BPSS1385
|
Name |
chbP
Synonym: cell cycle inhibiting factor Cif Synonym: cif |
Replicon | chromosome 2 |
Genomic location | 1893842 - 1894828 (- strand) |
Comment | CHBP contains a conserved catalytic triad (C156, H211, and Q231) that is important for cell cycle inhibition by deamindating Gln40 in ubiquitin (PMID: 20688984). |
RefSeq | YP_111397.1 |
GI | 53722412 |
Entrez | 3096526 |
GI | 53722412 |
INSDC | CAH38859.1 |
NCBI Locus Tag | BPSS1385 |
RefSeq | YP_111397.1,GeneID |
UniParc | UPI000043BC9B |
UniProtKB Acc | Q63KH5 |
UniProtKB ID | Q63KH5_BURPS |
UniRef100 | UniRef100_I1WTX4 |
UniRef50 | UniRef50_I1WTX4 |
UniRef90 | UniRef90_I1WTX4 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
Cif homolog in Burkholderia pseudomallei (CHBP)
|
Synonyms |
ATP/GTP binding protein |
Evidence for Translation | |
Charge (pH 7) | -1.10 |
Kyte-Doolittle Hydrophobicity Value | -0.356 |
Molecular Weight (kDa) | 35818.3 |
Isoelectric Point (pI) | 6.73 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
4HCP | PROTEIN BINDING | 10/01/12 | crystal structure of Burkholderia pseudomallei effector protein chbp in complex with nedd8 | BURKHOLDERIA PSEUDOMALLEI; HOMO SAPIENS | 2.52 | X-RAY DIFFRACTION | 99.6 |
3EIT | UNKNOWN FUNCTION | 09/17/08 | the 2.6 angstrom crystal structure of CHBP, the Cif Homologue from Burkholderia pseudomallei | BURKHOLDERIA PSEUDOMALLEI | 2.56 | X-RAY DIFFRACTION | 100.0 |
3EIR | UNKNOWN FUNCTION | 09/17/08 | Crystal structure of CHBP, a Cif Homologue from Burkholderia pseudomallei | BURKHOLDERIA PSEUDOMALLEI | 2.101 | X-RAY DIFFRACTION | 100.0 |
3GQM | UNKNOWN FUNCTION | 03/24/09 | Crystal structure of Cell Inhibiting Factor (Cif) from Burkholderia pseudomallei (CifBp) | BURKHOLDERIA PSEUDOMALLEI | 2.1 | X-RAY DIFFRACTION | 100.0 |
4HCN | PROTEIN BINDING | 09/30/12 | Crystal structure of Burkholderia pseudomallei effector protein CHBP in complex with ubiquitin | BURKHOLDERIA PSEUDOMALLEI; SACCHAROMYCES CEREVISIAE | 2.6 | X-RAY DIFFRACTION | 99.6 |
Results |
Pathogenic
Found only in pathogenic strains
Hits to this gene were found in 3 genera
|
Burkholderia Ortholog Group |
BG020859 (202 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BPSS1385
Search term: chbP
Search term: Cif homolog in Burkholderia pseudomallei (CHBP)
|
Analysis of the prevalence, secretion and function of a cell cycle-inhibiting factor in the melioidosis pathogen Burkholderia pseudomallei.
Pumirat P, Broek CV, Juntawieng N, Muangsombut V, Kiratisin P, Pattanapanyasat K, Stevens JM, Stevens MP, Korbsrisate S
PLoS One 2014;9(5):e96298
PubMed ID: 24809950
|
A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle.
Yao Q, Cui J, Zhu Y, Wang G, Hu L, Long C, Cao R, Liu X, Huang N, Chen S, Liu L, Shao F
Proc Natl Acad Sci U S A 2009 Mar 10;106(10):3716-21
PubMed ID: 19225106
|
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family.
Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, Liu L, Zheng N, Chen S, Shao F
Science 2010 Sep 3;329(5996):1215-8
PubMed ID: 20688984
|
Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif).
Ng MY, Wang M, Casey PJ, Gan YH, Hagen T
PLoS One 2017;12(2):e0171464
PubMed ID: 28166272
|