Burkholderia pseudomallei K96243, BPSS0687 (bprS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0687
Name
bprS
Replicon chromosome 2
Genomic location 928660 - 929988 (- strand)

Cross-References

RefSeq YP_110701.1
GI 53721716
Entrez 3095367
GI 53721716
INSDC CAH38147.1
NCBI Locus Tag BPSS0687
RefSeq YP_110701.1,GeneID
UniParc UPI000043B9F1
UniProtKB Acc Q63MH0
UniProtKB ID Q63MH0_BURPS
UniRef100 UniRef100_A0A069BET6
UniRef50 UniRef50_A3MEL6
UniRef90 UniRef90_A3MEL6

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component sensor kinase BprS
Product Name Confidence: Class 1
Synonyms sensor kinase
Evidence for Translation
Charge (pH 7) -4.18
Kyte-Doolittle Hydrophobicity Value -0.105
Molecular Weight (kDa) 48881.1
Isoelectric Point (pI) 6.39

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 621 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001187 (1112 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0687
Search term: bprS

Human Homologs

References

Perturbation of the two-component signal transduction system, BprRS, results in attenuated virulence and motility defects in Burkholderia pseudomallei.
Lazar Adler NR, Allwood EM, Deveson Lucas D, Harrison P, Watts S, Dimitropoulos A, Treerat P, Alwis P, Devenish RJ, Prescott M, Govan B, Adler B, Harper M, Boyce JD
BMC Genomics 2016 May 4;17:331
PubMed ID: 27147217