Burkholderia pseudomallei K96243, BPSS0355 (tyrB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0355
Name
tyrB
Replicon chromosome 2
Genomic location 495489 - 496688 (- strand)

Cross-References

RefSeq YP_110375.1
GI 53721390
Entrez 3095099
GI 53721390
INSDC CAH37803.1
NCBI Locus Tag BPSS0355
RefSeq YP_110375.1,GeneID
UniParc UPI000043B8B0
UniProtKB Acc Q63NE4
UniProtKB ID Q63NE4_BURPS
UniRef100 UniRef100_A0A069B6R7
UniRef50 UniRef50_O85746
UniRef90 UniRef90_A9AG25

Product

Feature Type CDS
Coding Frame 1
Product Name
aromatic amino acid aminotransferase
Synonyms
Evidence for Translation
Charge (pH 7) -0.12
Kyte-Doolittle Hydrophobicity Value 0.080
Molecular Weight (kDa) 42861.5
Isoelectric Point (pI) 6.94

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4F4E TRANSFERASE 05/10/12 Crystal structure of Aromatic-amino-acid aminotransferase from Burkholderia pseudomallei covalently bound to pyridoxal phosphate BURKHOLDERIA PSEUDOMALLEI 1.8 X-RAY DIFFRACTION 100.0
4EFF TRANSFERASE 03/29/12 Crystal structure of aromatic-amino-acid aminotransferase from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 1.85 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 187 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002099 (661 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0355
Search term: tyrB

Human Homologs

Ensembl 97, assembly GRCh38.p12
glutamic-oxaloacetic transaminase 2 [Source:HGNC Symbol;Acc:HGNC:4433]
E-value: 4.1e-90
Percent Identity: 44.8

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268