Burkholderia pseudomallei K96243, BPSL3424 (phhA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL3424
Name
phhA
Replicon chromosome 1
Genomic location 4066035 - 4066928 (+ strand)

Cross-References

RefSeq YP_110017.1
GI 53721031
Entrez 3091566
GI 53721031
INSDC CAH37436.1
NCBI Locus Tag BPSL3424
RefSeq YP_110017.1,GeneID
UniParc UPI000043B74C
UniProtKB Acc Q63PF2
UniProtKB ID Q63PF2_BURPS
UniRef100 UniRef100_Q62FU3
UniRef50 UniRef50_P30967
UniRef90 UniRef90_Q3JXT1

Product

Feature Type CDS
Coding Frame 1
Product Name
phenylalanine 4-monooxygenase
Synonyms
Evidence for Translation
Charge (pH 7) -7.37
Kyte-Doolittle Hydrophobicity Value -0.076
Molecular Weight (kDa) 33094.1
Isoelectric Point (pI) 5.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 124 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000064 (639 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL3424
Search term: phhA

Human Homologs

Ensembl 97, assembly GRCh38.p12
tryptophan hydroxylase 2 [Source:HGNC Symbol;Acc:HGNC:20692]
E-value: 4.1e-26
Percent Identity: 32.3

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268