Burkholderia pseudomallei K96243, BPSL3290 (ahcY)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL3290
Name
ahcY
Replicon chromosome 1
Genomic location 3906272 - 3907693 (- strand)

Cross-References

RefSeq YP_109886.1
GI 53720900
Entrez 3092196
GI 53720900
INSDC CAH37303.1
NCBI Locus Tag BPSL3290
RefSeq YP_109886.1,GeneID
UniParc UPI000043B6CC
UniProtKB Acc Q63PT2
UniProtKB ID SAHH_BURPS
UniRef100 UniRef100_A3MQW7
UniRef50 UniRef50_P50250
UniRef90 UniRef90_A3MQW7

Product

Feature Type CDS
Coding Frame 1
Product Name
S-adenosyl-L-homocysteine hydrolase
Synonyms
Evidence for Translation
Charge (pH 7) -9.08
Kyte-Doolittle Hydrophobicity Value -0.167
Molecular Weight (kDa) 52200.9
Isoelectric Point (pI) 6.06

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3GLQ HYDROLASE 03/12/09 Crystal structure of S-adenosyl-L-homocysteine hydrolase from Burkholderia pseudomallei in complex with 9-beta-D-arabino-furansyl-adenine BURKHOLDERIA PSEUDOMALLEI 1710B 2.3 X-RAY DIFFRACTION 100.0
3D64 HYDROLASE 05/18/08 Crystal structure of S-adenosyl-L-homocysteine hydrolase from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 2.3 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 499 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000178 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL3290
Search term: ahcY

Human Homologs

Ensembl 97, assembly GRCh38.p12
adenosylhomocysteinase [Source:HGNC Symbol;Acc:HGNC:343]
E-value: 6.1e-149
Percent Identity: 59.7

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268