Burkholderia pseudomallei K96243, BPSL3216 (fusA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL3216
Name
fusA
Replicon chromosome 1
Genomic location 3810679 - 3812781 (- strand)

Cross-References

RefSeq YP_109810.1
GI 53720824
Entrez 3092466
GI 53720824
INSDC CAH37227.1
NCBI Locus Tag BPSL3216
RefSeq YP_109810.1,GeneID
UniParc UPI000043B681
UniProtKB Acc Q63Q08
UniProtKB ID EFG2_BURPS
UniRef100 UniRef100_Q62GK2
UniRef50 UniRef50_P80868
UniRef90 UniRef90_Q62GK2

Product

Feature Type CDS
Coding Frame 1
Product Name
elongation factor G
Synonyms
Evidence for Translation
Charge (pH 7) -16.24
Kyte-Doolittle Hydrophobicity Value -0.323
Molecular Weight (kDa) 77445.9
Isoelectric Point (pI) 5.14

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000255 (1306 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL3216
Search term: fusA

Human Homologs

Ensembl 97, assembly GRCh38.p12
G elongation factor mitochondrial 1 [Source:HGNC Symbol;Acc:HGNC:13780]
E-value: 4.3e-151
Percent Identity: 43.8

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268