Burkholderia pseudomallei K96243, BPSL3101 (tssH-1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
Locus Tag
BPSL3101
Name
tssH-1
Synonym: clpB
Replicon chromosome 1
Genomic location 3704416 - 3707085 (- strand)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-1 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-1 cluster later (PMID:22007185)

Cross-References

RefSeq YP_109696.1
GI 53720710
Entrez 3094210
GI 53720710
INSDC CAH37112.1
NCBI Locus Tag BPSL3101
RefSeq YP_109696.1,GeneID
UniParc UPI000043B617
UniProtKB Acc Q63QC2
UniProtKB ID Q63QC2_BURPS
UniRef100 UniRef100_I1WF20
UniRef50 UniRef50_Q2SUD4
UniRef90 UniRef90_Q2SUD4

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssH-1
Product Name Confidence: Class 2
Synonyms protease associated ATPase ClpB
Evidence for Translation
Charge (pH 7) -21.01
Kyte-Doolittle Hydrophobicity Value -0.162
Molecular Weight (kDa) 96608.9
Isoelectric Point (pI) 5.33

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 597 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000372 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL3101
Search term: tssH-1

Human Homologs

Ensembl 86, assembly GRCh38.p7
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 3.6e-40
Percent Identity: 33.0

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS.
Microbiology. 2007 Aug;153(Pt 8):2689-99.
PubMed ID: 17660433
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA(1), Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D.
Mol Microbiol. 2007 Jun;64(6):1466-85.
PubMed ID: 17555434