Burkholderia pseudomallei K96243, BPSL2818 (purM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2818
Name
purM
Replicon chromosome 1
Genomic location 3369943 - 3370998 (- strand)

Cross-References

RefSeq YP_109413.1
GI 53720427
Entrez 3092877
GI 53720427
INSDC CAH36828.1
NCBI Locus Tag BPSL2818
RefSeq YP_109413.1,GeneID
UniParc UPI000043B501
UniProtKB Acc Q63R55
UniProtKB ID PUR5_BURPS
UniRef100 UniRef100_Q3JP21
UniRef50 UniRef50_Q2RSC8
UniRef90 UniRef90_Q2SYY5

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphoribosylaminoimidazole synthetase
Synonyms
Evidence for Translation
Charge (pH 7) -10.19
Kyte-Doolittle Hydrophobicity Value 0.117
Molecular Weight (kDa) 36941.1
Isoelectric Point (pI) 4.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database Victors : 2001
Category
Evidence ECO:0000015
mutant phenotype evidence
Host Organism Mus musculus
Notes purM mutant is avirulent in mice
Reference 17189432

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 622 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000637 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2818
Search term: purM

Human Homologs

Ensembl 97, assembly GRCh38.p12
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [Source:HGNC Symbol;Acc:HGNC:4163]
E-value: 3.2e-102
Percent Identity: 54.4
Ensembl 97, assembly GRCh38.p12
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [Source:HGNC Symbol;Acc:HGNC:4163]
E-value: 3.2e-102
Percent Identity: 54.4
Ensembl 97, assembly GRCh38.p12
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [Source:HGNC Symbol;Acc:HGNC:4163]
E-value: 3.2e-102
Percent Identity: 54.4

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268