Burkholderia pseudomallei K96243, BPSL2797 (wcbK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2797
Name
wcbK
Replicon chromosome 1
Genomic location 3343799 - 3344812 (- strand)

Cross-References

RefSeq YP_109392.1
GI 53720406
Entrez 3094198
GI 53720406
INSDC CAH36806.1
NCBI Locus Tag BPSL2797
RefSeq YP_109392.1,GeneID
UniParc UPI00000BEF85
UniProtKB Acc H7C736
UniProtKB ID H7C736_BURPS
UniRef100 UniRef100_Q7BMG5
UniRef50 UniRef50_Q29VV7
UniRef90 UniRef90_Q7BMG5

Product

Feature Type CDS
Coding Frame 1
Product Name
GDP sugar epimerase/dehydratase
Synonyms
Evidence for Translation
Charge (pH 7) -0.44
Kyte-Doolittle Hydrophobicity Value -0.235
Molecular Weight (kDa) 38057.1
Isoelectric Point (pI) 6.88

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0436
Category Type I O-polysaccharide
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 642 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG020188 (312 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2797
Search term: wcbK

Human Homologs

Ensembl 97, assembly GRCh38.p12
GDP-mannose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:4369]
E-value: 1.7e-31
Percent Identity: 27.8

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268