Burkholderia pseudomallei K96243, BPSL2758 (glyA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2758
Name
glyA
Replicon chromosome 1
Genomic location 3296909 - 3298156 (- strand)

Cross-References

RefSeq YP_109354.1
GI 53720368
Entrez 3094757
GI 53720368
INSDC CAH36766.1
NCBI Locus Tag BPSL2758
RefSeq YP_109354.1,GeneID
UniParc UPI000043B4D5
UniProtKB Acc Q63RB4
UniProtKB ID GLYA1_BURPS
UniRef100 UniRef100_Q62I16
UniRef50 UniRef50_P0A2E2
UniRef90 UniRef90_Q2SYS4

Product

Feature Type CDS
Coding Frame 1
Product Name
serine hydroxymethyltransferase
Synonyms
Evidence for Translation
Charge (pH 7) -0.90
Kyte-Doolittle Hydrophobicity Value -0.160
Molecular Weight (kDa) 44985.0
Isoelectric Point (pI) 6.86

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4MSO TRANSFERASE 09/18/13 X-ray crystal structure of a serine hydroxymethyl transferase in apo form from Burkholderia cenocepacia BURKHOLDERIA CENOCEPACIA 1.4 X-RAY DIFFRACTION 95.2
4OT8 TRANSFERASE 02/13/14 X-ray Crystal Structure of Serine Hydroxymethyl Transferase from Burkholderia cenocepacia bound to PLP and Serine BURKHOLDERIA CENOCEPACIA 2.0 X-RAY DIFFRACTION 95.2
4OTL TRANSFERASE 02/13/14 X-ray Crystal Structure of Serine Hydroxymethyl Transferase from Burkholderia cenocepacia bound to PLP and Glycine BURKHOLDERIA CENOCEPACIA 2.0 X-RAY DIFFRACTION 95.2
4N0W TRANSFERASE 10/02/13 X-ray crystal structure of a serine hydroxymethyltransferase from Burkholderia cenocepacia with covalently attached pyridoxal phosphate BURKHOLDERIA CENOCEPACIA 1.65 X-RAY DIFFRACTION 95.2

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 655 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000665 (642 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2758
Search term: glyA

Human Homologs

Ensembl 97, assembly GRCh38.p12
serine hydroxymethyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10852]
E-value: 9.0e-88
Percent Identity: 41.4
Ensembl 97, assembly GRCh38.p12
serine hydroxymethyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10852]
E-value: 9.0e-88
Percent Identity: 41.4
Ensembl 97, assembly GRCh38.p12
serine hydroxymethyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10852]
E-value: 9.0e-88
Percent Identity: 41.4
Ensembl 97, assembly GRCh38.p12
serine hydroxymethyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10852]
E-value: 9.0e-88
Percent Identity: 41.4

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268