Burkholderia pseudomallei K96243, BPSL2748

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2748
Name
Replicon chromosome 1
Genomic location 3291026 - 3291664 (- strand)

Cross-References

RefSeq YP_109344.1
GI 53720358
Entrez 3091891
GI 53720358
INSDC CAH36756.1
NCBI Locus Tag BPSL2748
RefSeq YP_109344.1,GeneID
UniParc UPI000043B4CB
UniProtKB Acc Q63RC4
UniProtKB ID Q63RC4_BURPS
UniRef100 UniRef100_A0A097XWU6
UniRef50 UniRef50_Q54SE2
UniRef90 UniRef90_C4KTT1

Product

Feature Type CDS
Coding Frame 1
Product Name
oxidoreductase
Synonyms
Evidence for Translation
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (20.5 kDa, pI 6.32, PMID:21960737)
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (24.7 kDa, pI 5.95, PMID:21960737)
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (24.6 kDa, pI 6.19, PMID:21960737)
Charge (pH 7) -2.83
Kyte-Doolittle Hydrophobicity Value -0.377
Molecular Weight (kDa) 23861.9
Isoelectric Point (pI) 6.03

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 574 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000675 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2748
Search term: oxidoreductase

Human Homologs

Ensembl 97, assembly GRCh38.p12
peroxiredoxin 6 [Source:HGNC Symbol;Acc:HGNC:16753]
E-value: 5.7e-62
Percent Identity: 52.9

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268