Burkholderia pseudomallei K96243, BPSL2697 (groEL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2697
Name
groEL
Replicon chromosome 1
Genomic location 3223479 - 3225119 (- strand)

Cross-References

RefSeq YP_109293.1
GI 53720307
Entrez 3094280
GI 53720307
INSDC CAH36705.1
NCBI Locus Tag BPSL2697
RefSeq YP_109293.1,GeneID
UniParc UPI000043B499
UniProtKB Acc Q9F712
UniProtKB ID CH601_BURPS
UniRef100 UniRef100_A3NCQ8
UniRef50 UniRef50_Q9C667
UniRef90 UniRef90_Q8Y1P8

Product

Feature Type CDS
Coding Frame 1
Product Name
molecular chaperone GroEL
Synonyms
Evidence for Translation
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (57.2 kDa, pI 4.95, PMID:21960737)
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (56.5 kDa, pI 5.00, PMID:21960737)
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (56.5 kDa, pI 4.97, PMID:21960737)
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (55.4 kDa, pI 5.06, PMID:21960737)
Charge (pH 7) -11.50
Kyte-Doolittle Hydrophobicity Value -0.044
Molecular Weight (kDa) 57115.2
Isoelectric Point (pI) 4.85

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 666 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000715 (1412 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2697
Search term: groEL

Human Homologs

Ensembl 97, assembly GRCh38.p12
heat shock protein family D (Hsp60) member 1 [Source:HGNC Symbol;Acc:HGNC:5261]
E-value: 2.2e-150
Percent Identity: 53.2
Ensembl 97, assembly GRCh38.p12
heat shock protein family D (Hsp60) member 1 [Source:HGNC Symbol;Acc:HGNC:5261]
E-value: 2.2e-150
Percent Identity: 53.2

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268