Burkholderia pseudomallei K96243, BPSL2677 (wbiD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2677
Name
wbiD
Replicon chromosome 1
Genomic location 3203353 - 3205077 (- strand)

Cross-References

RefSeq YP_109273.1
GI 53720287
Entrez 3093124
GI 53720287
INSDC CAH36685.1
NCBI Locus Tag BPSL2677
RefSeq YP_109273.1,GeneID
UniParc UPI000043B491
UniProtKB Acc Q63RJ5
UniProtKB ID Q63RJ5_BURPS
UniRef100 UniRef100_B1HEC0
UniRef50 UniRef50_A3NYE9
UniRef90 UniRef90_A3NYE9

Product

Feature Type CDS
Coding Frame 1
Product Name
O-antigen methyl transferase
Synonyms
Evidence for Translation
Detected in B. pseudomallei strain DD503 using trypsin shaving and mass spectrometry (PMID:21391724). Found in at least two preparations.
Charge (pH 7) -1.38
Kyte-Doolittle Hydrophobicity Value -0.295
Molecular Weight (kDa) 64808.6
Isoelectric Point (pI) 6.88

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization
Detected in Triton-insoluble fraction of lysozyme-treated B. pseudomallei DD503 cells using trypsin shaving and mass spectrometry (PMID:21391724).

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 59 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG020048 (300 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2677
Search term: wbiD

Human Homologs

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268