Burkholderia pseudomallei K96243, BPSL2648 (pcm)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2648
Name
pcm
Replicon chromosome 1
Genomic location 3171093 - 3171746 (+ strand)

Cross-References

RefSeq YP_109244.1
GI 53720258
Entrez 3093624
GI 53720258
INSDC CAH36656.1
NCBI Locus Tag BPSL2648
RefSeq YP_109244.1,GeneID
UniParc UPI000043B478
UniProtKB Acc Q63RM4
UniProtKB ID Q63RM4_BURPS
UniRef100 UniRef100_A0A069BA76
UniRef50 UniRef50_B4ECB7
UniRef90 UniRef90_A0A088X0S5

Product

Feature Type CDS
Coding Frame 1
Product Name
protein-L-isoaspartate O-methyltransferase
Synonyms
Evidence for Translation
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (24.9 kDa, pI 5.57, PMID:21960737)
Charge (pH 7) -2.55
Kyte-Doolittle Hydrophobicity Value -0.040
Molecular Weight (kDa) 24028.6
Isoelectric Point (pI) 5.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 429 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000766 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2648
Search term: pcm

Human Homologs

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268