Burkholderia pseudomallei K96243, BPSL2342 (hutU)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2342
Name
hutU
Replicon chromosome 1
Genomic location 2830050 - 2831738 (- strand)

Cross-References

RefSeq YP_108938.1
GI 53719952
Entrez 3091781
GI 53719952
INSDC CAH36345.1
NCBI Locus Tag BPSL2342
RefSeq YP_108938.1,GeneID
UniParc UPI000043B349
UniProtKB Acc Q63SH8
UniProtKB ID Q63SH8_BURPS
UniRef100 UniRef100_A0A069B301
UniRef50 UniRef50_P25080
UniRef90 UniRef90_Q141F7

Product

Feature Type CDS
Coding Frame 1
Product Name
urocanate hydratase
Synonyms
Evidence for Translation
Charge (pH 7) -4.07
Kyte-Doolittle Hydrophobicity Value -0.264
Molecular Weight (kDa) 61555.5
Isoelectric Point (pI) 6.56

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 266 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002063 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2342
Search term: hutU

Human Homologs

Ensembl 97, assembly GRCh38.p12
urocanate hydratase 1 [Source:HGNC Symbol;Acc:HGNC:26444]
E-value: 1.2e-82
Percent Identity: 33.4

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268