Burkholderia pseudomallei K96243, BPSL2304 (folD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2304
Name
folD
Replicon chromosome 1
Genomic location 2777000 - 2777857 (+ strand)

Cross-References

RefSeq YP_108900.1
GI 53719914
Entrez 3094333
GI 53719914
INSDC CAH36307.1
NCBI Locus Tag BPSL2304
RefSeq YP_108900.1,GeneID
UniParc UPI000043B323
UniProtKB Acc Q63SL6
UniProtKB ID FOLD_BURPS
UniRef100 UniRef100_Q3JQL8
UniRef50 UniRef50_P51696
UniRef90 UniRef90_Q3JQL8

Product

Feature Type CDS
Coding Frame 1
Product Name
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase
Synonyms
Evidence for Translation
Charge (pH 7) 2.80
Kyte-Doolittle Hydrophobicity Value 0.159
Molecular Weight (kDa) 29925.4
Isoelectric Point (pI) 8.01

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 621 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002033 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2304
Search term: folD

Human Homologs

Ensembl 97, assembly GRCh38.p12
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [Source:HGNC Symbol;Acc:HGNC:7434]
E-value: 5.3e-63
Percent Identity: 48.3

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268