Burkholderia pseudomallei K96243, BPSL2300 (pdhB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2300
Name
pdhB
Replicon chromosome 1
Genomic location 2768796 - 2770436 (- strand)

Cross-References

RefSeq YP_108896.1
GI 53719910
Entrez 3092156
GI 53719910
INSDC CAH36303.1
NCBI Locus Tag BPSL2300
RefSeq YP_108896.1,GeneID
UniParc UPI000043B31F
UniProtKB Acc Q63SM0
UniProtKB ID Q63SM0_BURPS
UniRef100 UniRef100_Q63SM0
UniRef50 UniRef50_A0A075P1Q2
UniRef90 UniRef90_A9AGT3

Product

Feature Type CDS
Coding Frame 1
Product Name
dihydrolipoamide acetyltransferase
Synonyms
Evidence for Translation
Charge (pH 7) -2.33
Kyte-Doolittle Hydrophobicity Value 0.036
Molecular Weight (kDa) 56295.0
Isoelectric Point (pI) 6.43

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 525 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002029 (629 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2300
Search term: pdhB

Human Homologs

Ensembl 97, assembly GRCh38.p12
pyruvate dehydrogenase complex component X [Source:HGNC Symbol;Acc:HGNC:21350]
E-value: 1.2e-31
Percent Identity: 30.5
Ensembl 97, assembly GRCh38.p12
pyruvate dehydrogenase complex component X [Source:HGNC Symbol;Acc:HGNC:21350]
E-value: 1.2e-31
Percent Identity: 30.5

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268