Burkholderia pseudomallei K96243, BPSL1403 (clpP)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1403
Name
clpP
Replicon chromosome 1
Genomic location 1631727 - 1632380 (+ strand)

Cross-References

RefSeq YP_108025.1
GI 53719039
Entrez 3094271
GI 53719039
INSDC CAH35404.1
NCBI Locus Tag BPSL1403
RefSeq YP_108025.1,GeneID
UniParc UPI000043AFBF
UniProtKB Acc Q63V41
UniProtKB ID CLPP_BURPS
UniRef100 UniRef100_A3MKJ8
UniRef50 UniRef50_Q46ID4
UniRef90 UniRef90_Q2SWQ6

Product

Feature Type CDS
Coding Frame 1
Product Name
ATP-dependent Clp protease proteolytic subunit
Synonyms
Evidence for Translation
Charge (pH 7) -2.83
Kyte-Doolittle Hydrophobicity Value -0.162
Molecular Weight (kDa) 23834.9
Isoelectric Point (pI) 6.02

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 582 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001787 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1403
Search term: clpP

Human Homologs

Ensembl 97, assembly GRCh38.p12
caseinolytic mitochondrial matrix peptidase proteolytic subunit [Source:HGNC Symbol;Acc:HGNC:2084]
E-value: 3.0e-58
Percent Identity: 56.1

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268