Burkholderia pseudomallei K96243, BPSL1351 (carB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1351
Name
carB
Replicon chromosome 1
Genomic location 1577195 - 1580449 (+ strand)

Cross-References

RefSeq YP_107976.1
GI 53718990
Entrez 3092518
GI 53718990
INSDC CAH35349.1
NCBI Locus Tag BPSL1351
RefSeq YP_107976.1,GeneID
UniParc UPI000043AF8E
UniProtKB Acc Q63V90
UniProtKB ID Q63V90_BURPS
UniRef100 UniRef100_A0A069B075
UniRef50 UniRef50_B9EXM2
UniRef90 UniRef90_A0K6B7

Product

Feature Type CDS
Coding Frame 1
Product Name
carbamoyl phosphate synthase large subunit
Synonyms
Evidence for Translation
Charge (pH 7) -30.75
Kyte-Doolittle Hydrophobicity Value -0.133
Molecular Weight (kDa) 118240.1
Isoelectric Point (pI) 4.87

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 622 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001129 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1351
Search term: carB

Human Homologs

Ensembl 97, assembly GRCh38.p12
carbamoyl-phosphate synthase 1 [Source:HGNC Symbol;Acc:HGNC:2323]
E-value: 6.8e-228
Percent Identity: 40.4
Ensembl 97, assembly GRCh38.p12
carbamoyl-phosphate synthase 1 [Source:HGNC Symbol;Acc:HGNC:2323]
E-value: 6.8e-228
Percent Identity: 40.4

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268