Burkholderia pseudomallei K96243, BPSL1218 (nuoH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1218
Name
nuoH
Replicon chromosome 1
Genomic location 1403954 - 1405018 (+ strand)

Cross-References

RefSeq YP_107840.1
GI 53718854
Entrez 3091497
GI 53718854
INSDC CAH35213.1
NCBI Locus Tag BPSL1218
RefSeq YP_107840.1,GeneID
UniParc UPI000043AF06
UniProtKB Acc Q63VM6
UniProtKB ID NUOH_BURPS
UniRef100 UniRef100_Q62IP2
UniRef50 UniRef50_P92558
UniRef90 UniRef90_Q62IP2

Product

Feature Type CDS
Coding Frame 1
Product Name
NADH dehydrogenase subunit H
Synonyms
Evidence for Translation
Charge (pH 7) 4.12
Kyte-Doolittle Hydrophobicity Value 0.982
Molecular Weight (kDa) 39187.5
Isoelectric Point (pI) 8.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 489 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002129 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1218
Search term: nuoH

Human Homologs

Ensembl 97, assembly GRCh38.p12
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 [Source:HGNC Symbol;Acc:HGNC:7455]
E-value: 2.4e-57
Percent Identity: 41.3

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268