Burkholderia pseudomallei K96243, BPSL1070 (parC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1070
Name
parC
Replicon chromosome 1
Genomic location 1237506 - 1239824 (+ strand)

Cross-References

RefSeq YP_107693.1
GI 53718707
Entrez 3093260
GI 53718707
INSDC CAH35065.1
NCBI Locus Tag BPSL1070
RefSeq YP_107693.1,GeneID
UniParc UPI000043AE73
UniProtKB Acc Q63W23
UniProtKB ID Q63W23_BURPS
UniRef100 UniRef100_A0A069B693
UniRef50 UniRef50_A1V1D8
UniRef90 UniRef90_A1V1D8

Product

Feature Type CDS
Coding Frame 1
Product Name
DNA topoisomerase IV subunit A
Synonyms
Evidence for Translation
Charge (pH 7) -2.17
Kyte-Doolittle Hydrophobicity Value -0.191
Molecular Weight (kDa) 83830.4
Isoelectric Point (pI) 6.67

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 630 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002239 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1070
Search term: parC

Human Homologs

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268