Burkholderia pseudomallei K96243, BPSL1006 (argH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1006
Name
argH
Replicon chromosome 1
Genomic location 1169883 - 1171292 (- strand)

Cross-References

RefSeq YP_107634.1
GI 53718648
Entrez 3092554
GI 53718648
INSDC CAH35002.1
NCBI Locus Tag BPSL1006
RefSeq YP_107634.1,GeneID
UniParc UPI000043AE38
UniProtKB Acc Q63W82
UniProtKB ID Q63W82_BURPS
UniRef100 UniRef100_A3MLL6
UniRef50 UniRef50_P59618
UniRef90 UniRef90_P59615

Product

Feature Type CDS
Coding Frame 1
Product Name
argininosuccinate lyase
Synonyms
Evidence for Translation
Charge (pH 7) -8.73
Kyte-Doolittle Hydrophobicity Value -0.109
Molecular Weight (kDa) 51172.8
Isoelectric Point (pI) 5.90

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 625 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002300 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1006
Search term: argH

Human Homologs

Ensembl 97, assembly GRCh38.p12
argininosuccinate lyase [Source:HGNC Symbol;Acc:HGNC:746]
E-value: 6.8e-92
Percent Identity: 39.7
Ensembl 97, assembly GRCh38.p12
argininosuccinate lyase [Source:HGNC Symbol;Acc:HGNC:746]
E-value: 6.8e-92
Percent Identity: 39.7

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268