Burkholderia pseudomallei K96243, BPSL0281 (flgL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL0281
Name
flgL
Replicon chromosome 1
Genomic location 293438 - 294670 (+ strand)

Cross-References

RefSeq YP_106908.1
GI 53717922
Entrez 3093211
GI 53717922
INSDC CAH34269.1
NCBI Locus Tag BPSL0281
RefSeq YP_106908.1,GeneID
UniParc UPI000043AB69
UniProtKB Acc Q63YA7
UniProtKB ID Q63YA7_BURPS
UniRef100 UniRef100_A0A069AX15
UniRef50 UniRef50_A0A038H321
UniRef90 UniRef90_Q2T1Z0

Product

Feature Type CDS
Coding Frame 1
Product Name
flagellar hook-associated protein FlgL
Synonyms
Evidence for Translation
Charge (pH 7) -8.29
Kyte-Doolittle Hydrophobicity Value -0.054
Molecular Weight (kDa) 42095.4
Isoelectric Point (pI) 4.33

Subcellular localization

Individual Mappings
Localization Confidence PMID
Flagellar
Note: This is based on PSORTb V3.0 secondary localization prediction
 Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0430
Category Flagella
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 218 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002839 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL0281
Search term: flgL

Human Homologs

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268