Burkholderia pseudomallei K96243, BPSL0280 (flgK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL0280
Name
flgK
Replicon chromosome 1
Genomic location 291419 - 293422 (+ strand)

Cross-References

RefSeq YP_106907.1
GI 53717921
Entrez 3093210
GI 53717921
INSDC CAH34268.1
NCBI Locus Tag BPSL0280
RefSeq YP_106907.1,GeneID
UniParc UPI000043AB68
UniProtKB Acc Q63YA8
UniProtKB ID Q63YA8_BURPS
UniRef100 UniRef100_C4KMY6
UniRef50 UniRef50_R4WJB9
UniRef90 UniRef90_Q2T1Z1

Product

Feature Type CDS
Coding Frame 1
Product Name
flagellar hook-associated protein FlgK
Synonyms
Evidence for Translation
Charge (pH 7) -6.02
Kyte-Doolittle Hydrophobicity Value -0.051
Molecular Weight (kDa) 67377.9
Isoelectric Point (pI) 4.47

Subcellular localization

Individual Mappings
Localization Confidence PMID
Flagellar
Note: This is based on PSORTb V3.0 secondary localization prediction
 Class 3
Extracellular Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4UT1 MOTOR PROTEIN 07/17/14 The structure of the flagellar hook junction protein FlgK from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI K96243 1.8 X-RAY DIFFRACTION 100.0

Virulence Evidence

Source 1
Database VFDB : VF0430
Category Flagella
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 303 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002840 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL0280
Search term: flgK

Human Homologs

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268