Burkholderia pseudomallei K96243, BPSL0268

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL0268
Name
Replicon chromosome 1
Genomic location 280340 - 280684 (- strand)

Cross-References

RefSeq YP_106895.1
GI 53717909
Entrez 3094414
GI 53717909
INSDC CAH34256.1
NCBI Locus Tag BPSL0268
RefSeq YP_106895.1,GeneID
UniParc UPI000043AB5D
UniProtKB Acc Q63YC0
UniProtKB ID Q63YC0_BURPS
UniRef100 UniRef100_A0A069B3Z4
UniRef50 UniRef50_Q2T203
UniRef90 UniRef90_Q2T203

Product

Feature Type CDS
Coding Frame 1
Product Name
negative regulator of flagellin synthesis
Synonyms
Evidence for Translation
Charge (pH 7) 0.98
Kyte-Doolittle Hydrophobicity Value -0.239
Molecular Weight (kDa) 11119.0
Isoelectric Point (pI) 9.37

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0430
Category Flagella
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 34 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002852 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL0268

Human Homologs

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268