Burkholderia cenocepacia H111, I35_RS20345 (bceA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia H111
GCF_000236215.2|latest
Locus Tag
I35_RS20345
NCBI Old Locus TagI35_4767%2CI35_4784
Name
bceA
Synonym: cpsB
Replicon chromosome 2
Genomic location 850526 - 852067 (- strand)
CommentMember of the bce-I gene cluster

Cross-References

RefSeq WP_043205676.1
GI 759484747
NCBI Locus Tag I35_RS20345
NCBI Old Locus Tag I35_4767%2CI35_4784
RefSeq WP_043205676.1

Product

Feature Type CDS
Coding Frame 1
Product Name
bifunctional exopolysaccharide biosynthesis protein (phosphomannose isomerase and GDP-D-mannose pyrophosphorylase) BceA
Product Name Confidence: Class 1
Synonyms mannose-1-phosphate guanyltransferase
Evidence for Translation
Charge (pH 7) -6.32
Kyte-Doolittle Hydrophobicity Value -0.142
Molecular Weight (kDa) 55771.8
Isoelectric Point (pI) 6.43

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003312 (1226 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: I35_RS20345
Search term: bceA

Human Homologs

References

Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863
The Burkholderia cepacia bceA gene encodes a protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activities.
Sousa SA, Moreira LM, Wopperer J, Eberl L, Sá-Correia I, Leitão JH
Biochem Biophys Res Commun 2007 Feb 2;353(1):200-6
PubMed ID: 17184737
Functional analysis of the Burkholderia cenocepacia J2315 BceAJ protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activities.
Sousa SA, Moreira LM, Leitão JH
Appl Microbiol Biotechnol 2008 Oct;80(6):1015-22
PubMed ID: 18668237