Burkholderia cenocepacia H111, I35_RS01760 (tagL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia H111
GCF_000236215.2|latest
Locus Tag
I35_RS01760
NCBI Old Locus TagI35_0340%2CI35_0377
Name
tagL
Synonym: bcsD
Replicon chromosome 1
Genomic location 361971 - 362921 (- strand)
CommentPart of the T6SS gene cluster

Cross-References

RefSeq WP_006494417.1
GI 493540541
NCBI Locus Tag I35_RS01760
NCBI Old Locus Tag I35_0340%2CI35_0377
RefSeq WP_006494417.1

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system-associated protein TagL
Product Name Confidence: Class 2
Synonyms cell envelope biogenesis protein OmpA
Evidence for Translation
Charge (pH 7) 7.95
Kyte-Doolittle Hydrophobicity Value -0.254
Molecular Weight (kDa) 32760.8
Isoelectric Point (pI) 10.42

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000376 (645 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: I35_RS01760
Search term: tagL

Human Homologs

References

A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
Anchoring the type VI secretion system to the peptidoglycan: TssL, TagL, TagP... what else?
Aschtgen MS, Thomas MS, Cascales E
Virulence 2010 Nov-Dec;1(6):535-40
PubMed ID: 21178498
Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.
Aubert DF, Hu S, Valvano MA
Microbiology 2015 Nov;161(11):2161-73
PubMed ID: 26364149