Burkholderia cenocepacia H111, I35_RS01750 (tssH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia H111
GCF_000236215.2|latest
Locus Tag
I35_RS01750
NCBI Old Locus TagI35_0338%2CI35_0379
Name
tssH
Synonym: clpV
Replicon chromosome 1
Genomic location 358042 - 360711 (+ strand)
CommentPart of the T6SS gene cluster

Cross-References

RefSeq WP_006494419.1
GI 493540543
NCBI Locus Tag I35_RS01750
NCBI Old Locus Tag I35_0338%2CI35_0379
RefSeq WP_006494419.1

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssH
Product Name Confidence: Class 1
Synonyms ATPase
Evidence for Translation
Charge (pH 7) -25.53
Kyte-Doolittle Hydrophobicity Value -0.166
Molecular Weight (kDa) 96659.1
Isoelectric Point (pI) 5.16

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000372 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: I35_RS01750
Search term: tssH

Human Homologs

Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 3.9e-40
Percent Identity: 33.8
Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 3.9e-40
Percent Identity: 33.8
Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 3.9e-40
Percent Identity: 33.8
Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 3.9e-40
Percent Identity: 33.8
Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 3.9e-40
Percent Identity: 33.8

References

A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion.
Bönemann G, Pietrosiuk A, Diemand A, Zentgraf H, Mogk A
EMBO J 2009 Feb 18;28(4):315-25
PubMed ID: 19131969
Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.
Aubert DF, Hu S, Valvano MA
Microbiology 2015 Nov;161(11):2161-73
PubMed ID: 26364149