Burkholderia lata 383, BCEP18194_RS34105 (bceC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia lata 383
Locus Tag
BCEP18194_RS34105
NCBI Old Locus TagBcep18194_B2275
Name
bceC
Replicon chromosome 2
Genomic location 2598098 - 2599510 (- strand)
CommentMember of the bce-I gene cluster

Cross-References

RefSeq WP_011355868.1
GI 499675134
NCBI Locus Tag BCEP18194_RS34105
NCBI Old Locus Tag Bcep18194_B2275
RefSeq WP_011355868.1

Product

Feature Type CDS
Coding Frame NA
Product Name
UDP-Glucose Dehydrogenase BceC
Product Name Confidence: Class 2
Synonyms UDP-glucose 6-dehydrogenase
Evidence for Translation
Charge (pH 7) -9.20
Kyte-Doolittle Hydrophobicity Value -0.148
Molecular Weight (kDa) 51238.6
Isoelectric Point (pI) 5.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2Y0C OXIDOREDUCTASE 12/02/10 BceC mutation Y10S BURKHOLDERIA CEPACIA 1.75 X-RAY DIFFRACTION 98.7
2Y0D OXIDOREDUCTASE 12/02/10 BceC mutation Y10K BURKHOLDERIA CEPACIA 2.8 X-RAY DIFFRACTION 98.7
2Y0E OXIDOREDUCTASE 12/02/10 BceC and the final step of UGDs reaction BURKHOLDERIA CEPACIA 1.75 X-RAY DIFFRACTION 98.9

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000893 (1284 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCEP18194_RS34105
Search term: bceC

Human Homologs

Ensembl 86, assembly GRCh38.p7
UDP-glucose 6-dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12525]
E-value: 7.8e-66
Percent Identity: 35.8

References

Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS(1), Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM.
Appl Environ Microbiol. 2010 Jan;76(2):441-50.
PubMed ID: 19948863
PubMed ID: 21602353
PubMed ID: 20208157