Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS02225 (htrA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
BURCENK562V_RS02225
NCBI Old Locus TagBURCENK562V_C0217
Name
htrA
Replicon ctg7180000002936
Genomic location 92591 - 94075 (- strand)

Cross-References

RefSeq WP_006490099.1
GI 493536148
EC Number 3.4.21.-
GI 493536148
NCBI Locus Tag BURCENK562V_RS02225
NCBI Old Locus Tag BURCENK562V_C0217
RefSeq WP_006490099.1

Product

Feature Type CDS
Coding Frame 1
Product Name
HtrA protease
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) 2.20
Kyte-Doolittle Hydrophobicity Value -0.022
Molecular Weight (kDa) 50966.4
Isoelectric Point (pI) 8.66

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 1
Western blot evidence used in manual assertion
Periplasmic Class 3
Periplasmic Class 3
Additional evidence for subcellular localization

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002475 (677 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: htrA
Search term: HtrA protease

Human Homologs

Ensembl 83, assembly GRCh38
HtrA serine peptidase 3 [Source:HGNC Symbol;Acc:HGNC:30406]
E-value: 2.7e-37
Percent Identity: 37.1

References

Burkholderia cenocepacia requires a periplasmic HtrA protease for growth under thermal and osmotic stress and for survival in vivo.
Flannagan RS, Aubert D, Kooi C, Sokol PA, Valvano MA.
Infect Immun. 2007 Apr;75(4):1679-89.
PubMed ID: 17220310