Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS01875 (lpxK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest
Locus Tag
BURCENK562V_RS01875
NCBI Old Locus TagBURCENK562V_C0145
Name
lpxK
Replicon ctg7180000002936
Genomic location 16996 - 18024 (+ strand)

Cross-References

RefSeq WP_006493682.1
GI 493539799
GI 493539799
NCBI Locus Tag BURCENK562V_RS01875
NCBI Old Locus Tag BURCENK562V_C0145
RefSeq WP_006493682.1

Product

Feature Type CDS
Coding Frame 1
Product Name
LpxK
Product Name Confidence: Class 2
Synonyms tetraacyldisaccharide 4'-kinase
Evidence for Translation
Charge (pH 7) 7.35
Kyte-Doolittle Hydrophobicity Value 0.107
Molecular Weight (kDa) 36265.3
Isoelectric Point (pI) 9.71

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002408 (651 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: lpxK
Search term: LpxK

Human Homologs

References

The LpxL acyltransferase is required for normal growth and penta-acylation of lipid A in Burkholderia cenocepacia.
Fathy Mohamed Y, Hamad M, Ortega XP, Valvano MA
Mol Microbiol 2017 Apr;104(1):144-162
PubMed ID: 28085228