Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS06245 (dfsA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
BURCENK562V_RS06245
NCBI Old Locus TagBURCENK562V_C2565
Name
dfsA
Synonym: rpfF
Replicon ctg7180000002940B
Genomic location 69118 - 69981 (- strand)

Cross-References

RefSeq WP_006488766.1
GI 493534800
EC Number 4.2.1.17
GI 493534800
NCBI Locus Tag BURCENK562V_RS06245
NCBI Old Locus Tag BURCENK562V_C2565
RefSeq WP_006488766.1

Product

Feature Type CDS
Coding Frame 1
Product Name
diffusible factor synthase A
Product Name Confidence: Class 2
Synonyms enoyl-CoA hydratase
Evidence for Translation
Charge (pH 7) -3.68
Kyte-Doolittle Hydrophobicity Value 0.006
Molecular Weight (kDa) 32000.4
Isoelectric Point (pI) 5.97

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5FUS LYASE 01/29/16 Crystal structure of B. cenocepacia DfsA BURKHOLDERIA CENOCEPACIA 1.87 X-RAY DIFFRACTION 100.0

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004647 (313 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: dfsA

References

A novel DSF-like signal from Burkholderia cenocepacia interferes with Candida albicans morphological transition.
Boon C, Deng Y, Wang LH, He Y, Xu JL, Fan Y, Pan SQ, Zhang LH.
ISME J. 2008 Jan;2(1):27-36.
PubMed ID: 18049456
PubMed ID: 23231487
PubMed ID: 25681189
PubMed ID: 26725701
The Burkholderia cenocepacia BDSF quorum sensing fatty acid is synthesized by a bifunctional crotonase homologue having both dehydratase and thioesterase activities.
Bi H, Christensen QH, Feng Y, Wang H, Cronan JE.
Mol Microbiol. 2012 Feb;83(4):840-55.
PubMed ID: 22221091