Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS29160 (kdoO)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest
Locus Tag
BURCENK562V_RS29160
NCBI Old Locus TagBURCENK562V_C5764
Name
kdoO
Synonym: wbxY
Replicon ctg7180000002940C
Genomic location 123394 - 124278 (+ strand)
CommentResponsible for Ko formation with Kdo2-lipid A as a substrate

Cross-References

RefSeq WP_006485119.1
GI 493531116
GI 493531116
NCBI Locus Tag BURCENK562V_RS29160
NCBI Old Locus Tag BURCENK562V_C5764
RefSeq WP_006485119.1

Product

Feature Type CDS
Coding Frame 1
Product Name
Kdo 3-hydroxylase KdoO
Product Name Confidence: Class 2
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 3.59
Kyte-Doolittle Hydrophobicity Value -0.222
Molecular Weight (kDa) 32740.3
Isoelectric Point (pI) 8.48

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000751 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: kdoO

Human Homologs

References

The LpxL acyltransferase is required for normal growth and penta-acylation of lipid A in Burkholderia cenocepacia.
Fathy Mohamed Y, Hamad M, Ortega XP, Valvano MA
Mol Microbiol 2017 Apr;104(1):144-162
PubMed ID: 28085228
Dioxygenases in Burkholderia ambifaria and Yersinia pestis that hydroxylate the outer Kdo unit of lipopolysaccharide.
Chung HS, Raetz CR
Proc Natl Acad Sci U S A 2011 Jan 11;108(2):510-5
PubMed ID: 21178073
Kdo hydroxylase is an inner core assembly enzyme in the Ko-containing lipopolysaccharide biosynthesis.
Chung HS, Yang EG, Hwang D, Lee JE, Guan Z, Raetz CR
Biochem Biophys Res Commun 2014 Sep 26;452(3):789-94
PubMed ID: 25204504