Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS32320

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
BURCENK562V_RS32320
NCBI Old Locus TagBURCENK562V_C7175
Name
Synonym: PaaZ-ECH
Replicon ctg7180000002943
Genomic location 279396 - 279854 (- strand)
CommentIn E. coli, paaZ encodes a bifunctional protein consisting of an N-terminal NADP-dependent aldehyde dehydrogenase domain and a C-terminal MaoC-like (R)-specific enoyl-CoA hydratase domain. In Burkholderia genomes, a gene incorrectly annotated as paaZ (e.g WQ49_RS11500) encodes only one of the two domains found in E.coli paaZ (the domain with semialdehyde dehydrogenase activity) and so is renamed PacL (PMID:21296885) but was also referred to as PaaZ-ALDH in the manuscript. In the same study , a separate A. aromaticum, protein (UniProtKB:Q5P232) with the (R)-hydratase activity was annotated as Ech-Aa and the Burkholderia ortholog was annotated as PaaZ-ECH.

Cross-References

RefSeq WP_006483300.1
GI 493529284
GI 493529284
NCBI Locus Tag BURCENK562V_RS32320
NCBI Old Locus Tag BURCENK562V_C7175
RefSeq WP_006483300.1

Product

Feature Type CDS
Coding Frame 1
Product Name
putative (R)-specific oxepin-CoA hydratase
Product Name Confidence: Class 2
Synonyms acyl dehydratase
Evidence for Translation
Charge (pH 7) -2.63
Kyte-Doolittle Hydrophobicity Value -0.153
Molecular Weight (kDa) 16901.1
Isoelectric Point (pI) 6.23

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG005317 (313 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:

References

PubMed ID: 21296885