Burkholderia pseudomallei 1026b, BP1026B_II0540 (hmqF)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia pseudomallei 1026b - Assembly GCF_000260515.1
GCF_000260515.1|latest |
| Locus Tag |
BP1026B_II0540
|
| NCBI Locus Tag | BP1026B_RS21275 |
| Name |
hmqF
|
| Replicon | chromosome 2 |
| Genomic location | 663470 - 667303 (+ strand) |
| Comment | Belongs to the HMAQ biosynthesis operon hmqABCDEFG |
Cross-References
| RefSeq | WP_004553201.1 |
| GI | |
| Entrez | 12833198 |
| NCBI Locus Tag | BP1026B_RS21275 |
| NCBI Old Locus Tag | BP1026B_II0540 |
| RefSeq | WP_004553201.1 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
polyketide synthase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -10.48 |
| Kyte-Doolittle Hydrophobicity Value | -0.086 |
| Molecular Weight (kDa) | 137284.6 |
| Isoelectric Point (pI) | 6.30 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 588 genera
|
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG017410 (460 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: BP1026B_II0540
Search term: hmqF
Search term: polyketide synthase
|
Human Homologs
|
Ensembl
97, assembly
GRCh38.p12
|
acyl-CoA synthetase family member 3 [Source:HGNC Symbol;Acc:HGNC:27288]
E-value:
2.6e-16
Percent Identity:
22.7
|
|
Ensembl
97, assembly
GRCh38.p12
|
acyl-CoA synthetase family member 3 [Source:HGNC Symbol;Acc:HGNC:27288]
E-value:
2.6e-16
Percent Identity:
22.7
|
|
Ensembl
97, assembly
GRCh38.p12
|
acyl-CoA synthetase family member 3 [Source:HGNC Symbol;Acc:HGNC:27288]
E-value:
2.6e-16
Percent Identity:
22.7
|
References
|
Burkholderia pseudomallei, B. thailandensis, and B. ambifaria produce 4-hydroxy-2-alkylquinoline analogues with a methyl group at the 3 position that is required for quorum-sensing regulation.
Vial L, Lépine F, Milot S, Groleau MC, Dekimpe V, Woods DE, Déziel E
J Bacteriol 2008 Aug;190(15):5339-52
PubMed ID: 18539738
|
|
Interplay between 4-Hydroxy-3-Methyl-2-Alkylquinoline and <i>N</i>-Acyl-Homoserine Lactone Signaling in a <i>Burkholderia cepacia</i> Complex Clinical Strain.
Chapalain A, Groleau MC, Le Guillouzer S, Miomandre A, Vial L, Milot S, Déziel E
Front Microbiol 2017;8:1021
PubMed ID: 28676791
|