Burkholderia pseudomallei 1026b, BP1026B_II0537 (hmqC)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia pseudomallei 1026b - Assembly GCF_000260515.1
GCF_000260515.1|latest |
| Locus Tag |
BP1026B_II0537
|
| NCBI Locus Tag | BP1026B_RS21260 |
| Name |
hmqC
|
| Replicon | chromosome 2 |
| Genomic location | 660322 - 661449 (+ strand) |
| Comment | Belongs to the HMAQ biosynthesis operon hmqABCDEFG |
Cross-References
| RefSeq | |
| GI | |
| Entrez | 12833195 |
| NCBI Locus Tag | BP1026B_RS21260 |
| NCBI Old Locus Tag | BP1026B_II0537 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
beta-ketoacyl-ACP synthase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -5.45 |
| Kyte-Doolittle Hydrophobicity Value | -0.161 |
| Molecular Weight (kDa) | 41255.3 |
| Isoelectric Point (pI) | 5.70 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 558 genera
|
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG017406 (462 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: BP1026B_II0537
Search term: hmqC
Search term: beta-ketoacyl-ACP synthase
|
Human Homologs
References
|
Burkholderia pseudomallei, B. thailandensis, and B. ambifaria produce 4-hydroxy-2-alkylquinoline analogues with a methyl group at the 3 position that is required for quorum-sensing regulation.
Vial L, Lépine F, Milot S, Groleau MC, Dekimpe V, Woods DE, Déziel E
J Bacteriol 2008 Aug;190(15):5339-52
PubMed ID: 18539738
|
|
Interplay between 4-Hydroxy-3-Methyl-2-Alkylquinoline and <i>N</i>-Acyl-Homoserine Lactone Signaling in a <i>Burkholderia cepacia</i> Complex Clinical Strain.
Chapalain A, Groleau MC, Le Guillouzer S, Miomandre A, Vial L, Milot S, Déziel E
Front Microbiol 2017;8:1021
PubMed ID: 28676791
|