Burkholderia pseudomallei 1026b, BP1026B_II0535 (hmqA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei 1026b - Assembly GCF_000260515.1
GCF_000260515.1|latest
Locus Tag
BP1026B_II0535
NCBI Locus TagBP1026B_RS21250
Name
hmqA
Replicon chromosome 2
Genomic location 657741 - 659366 (+ strand)
CommentBelongs to the HMAQ biosynthesis operon hmqABCDEFG

Cross-References

RefSeq WP_004553200.1
GI
Entrez 12833193
NCBI Locus Tag BP1026B_RS21250
NCBI Old Locus Tag BP1026B_II0535
RefSeq WP_004553200.1

Product

Feature Type CDS
Coding Frame 1
Product Name
2-aminobenzoate-CoA ligase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 0.16
Kyte-Doolittle Hydrophobicity Value 0.044
Molecular Weight (kDa) 58364.2
Isoelectric Point (pI) 7.02

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 601 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG017403 (474 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BP1026B_II0535
Search term: hmqA

Human Homologs

Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase medium chain family member 3 [Source:HGNC Symbol;Acc:HGNC:10522]
E-value: 2.2e-49
Percent Identity: 30.3

References

Burkholderia pseudomallei, B. thailandensis, and B. ambifaria produce 4-hydroxy-2-alkylquinoline analogues with a methyl group at the 3 position that is required for quorum-sensing regulation.
Vial L, Lépine F, Milot S, Groleau MC, Dekimpe V, Woods DE, Déziel E
J Bacteriol 2008 Aug;190(15):5339-52
PubMed ID: 18539738
Interplay between 4-Hydroxy-3-Methyl-2-Alkylquinoline and <i>N</i>-Acyl-Homoserine Lactone Signaling in a <i>Burkholderia cepacia</i> Complex Clinical Strain.
Chapalain A, Groleau MC, Le Guillouzer S, Miomandre A, Vial L, Milot S, Déziel E
Front Microbiol 2017;8:1021
PubMed ID: 28676791