Burkholderia cenocepacia J2315, BCAL3130 (wzt)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL3130
NCBI Locus Tag	QU43_RS52370
Name	wzt
Replicon	chromosome 1
Genomic location	3421647 - 3422960 (- strand)
Comment	Belongs to the O antigen biosynthesis gene cluster

Cross-References

RefSeq	WP_012492907.1
GI	206561474
Entrez	6934234
GI	206561474
INSDC	CAR53453.1
NCBI Locus Tag	QU43_RS52370
NCBI Old Locus Tag	BCAL3130
RefSeq	WP_012492907.1,GeneID
UniParc	UPI00017B9991
UniProtKB Acc	B4ECF0
UniProtKB ID	B4ECF0_BURCJ
UniRef100	UniRef100_B4ECF0
UniRef50	UniRef50_Q3K8W9
UniRef90	UniRef90_B4ECF0

Product

Feature Type	CDS
Coding Frame	1
Product Name	ABC transporter ATP-binding protein Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7)	-9.95
Kyte-Doolittle Hydrophobicity Value	-0.004
Molecular Weight (kDa)	48125.4
Isoelectric Point (pI)	5.58

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG000727 (655 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL3130 Search term: wzt Search term: ABC transporter ATP-binding protein

Human Homologs

Ensembl 97, assembly GRCh38.p12

ENSP00000269081 ATP binding cassette subfamily A member 10 [Source:HGNC Symbol;Acc:HGNC:30] E-value: 7.6e-21 Percent Identity: 28.4

References

Reconstitution of O-specific lipopolysaccharide expression in Burkholderia cenocepacia strain J2315, which is associated with transmissible infections in patients with cystic fibrosis. Ortega X, Hunt TA, Loutet S, Vinion-Dubiel AD, Datta A, Choudhury B, Goldberg JB, Carlson R, Valvano MA J Bacteriol 2005 Feb;187(4):1324-33 PubMed ID: 15687196