Burkholderia cenocepacia J2315, BCAL2303 (tyrB)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL2303
NCBI Locus Tag	QU43_RS48150
Name	tyrB
Replicon	chromosome 1
Genomic location	2554639 - 2555838 (+ strand)

Cross-References

RefSeq	WP_006483879.1
GI	206560663
Entrez	6934230
GI	206560663
INSDC	CAR52604.1
NCBI Locus Tag	QU43_RS48150
NCBI Old Locus Tag	BCAL2303
RefSeq	WP_006483879.1,GeneID
UniParc	UPI00017B9716
UniProtKB Acc	B4EEP2
UniProtKB ID	B4EEP2_BURCJ
UniRef100	UniRef100_B4EEP2
UniRef50	UniRef50_O85746
UniRef90	UniRef90_A9AG25

Product

Feature Type	CDS
Coding Frame	1
Product Name	aromatic amino acid aminotransferase
Synonyms
Evidence for Translation
Charge (pH 7)	-0.89
Kyte-Doolittle Hydrophobicity Value	0.097
Molecular Weight (kDa)	42561.0
Isoelectric Point (pI)	6.68

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
4F4E	TRANSFERASE	05/10/12	Crystal structure of Aromatic-amino-acid aminotransferase from Burkholderia pseudomallei covalently bound to pyridoxal phosphate	BURKHOLDERIA PSEUDOMALLEI	1.8	X-RAY DIFFRACTION	90.2
4EFF	TRANSFERASE	03/29/12	Crystal structure of aromatic-amino-acid aminotransferase from Burkholderia pseudomallei	BURKHOLDERIA PSEUDOMALLEI	1.85	X-RAY DIFFRACTION	90.2

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 199 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG002099 (661 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL2303 Search term: tyrB Search term: aromatic amino acid aminotransferase

Human Homologs

Ensembl 97, assembly GRCh38.p12

ENSP00000245206 glutamic-oxaloacetic transaminase 2 [Source:HGNC Symbol;Acc:HGNC:4433] E-value: 8.7e-88 Percent Identity: 44.2

References