Burkholderia cenocepacia J2315, BCAM2756 (cblR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM2756
NCBI Locus TagQU43_RS68240
Name
cblR
Replicon chromosome 2
Genomic location 3115330 - 3116046 (- strand)

Cross-References

RefSeq WP_012493630.1
GI 206564594
Entrez 6930262
GI 206564594
INSDC CAR56620.1
NCBI Locus Tag QU43_RS68240
NCBI Old Locus Tag BCAM2756
RefSeq WP_012493630.1,GeneID
UniParc UPI00003785A1
UniProtKB Acc B4ELF5
UniProtKB ID B4ELF5_BURCJ
UniRef100 UniRef100_Q6JE31
UniRef50 UniRef50_Q6JE31
UniRef90 UniRef90_Q6JE31

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component regulatory system response regulator protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 0.62
Kyte-Doolittle Hydrophobicity Value -0.134
Molecular Weight (kDa) 25770.1
Isoelectric Point (pI) 7.22

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 466 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002626 (181 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2756
Search term: cblR

Human Homologs

References

The emergence of a highly transmissible lineage of cbl+ Pseudomonas (Burkholderia) cepacia causing CF centre epidemics in North America and Britain.
Sun L, Jiang RZ, Steinbach S, Holmes A, Campanelli C, Forstner J, Sajjan U, Tan Y, Riley M, Goldstein R
Nat Med 1995 Jul;1(7):661-6
PubMed ID: 7585148
Erratum in: J Bacteriol. 2009 Apr;191(8):2907.
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
J Bacteriol. 2009 Jan;191(1):261-77.
PubMed ID: 18931103
Cable pili and the 22-kilodalton adhesin are required for Burkholderia cenocepacia binding to and transmigration across the squamous epithelium.
Urban TA, Goldberg JB, Forstner JF, Sajjan US
Infect Immun 2005 Sep;73(9):5426-37
PubMed ID: 16113259
Genetic characterization of a multicomponent signal transduction system controlling the expression of cable pili in Burkholderia cenocepacia.
Tomich M, Mohr CD
J Bacteriol 2004 Jun;186(12):3826-36
PubMed ID: 15175296