Strain |
Burkholderia cenocepacia J2315
GCF_000009485.1|latest |
Locus Tag |
BCAL2944
|
NCBI Locus Tag | QU43_RS51365 |
Name |
hldD
|
Replicon | chromosome 1 |
Genomic location | 3222190 - 3223182 (- strand) |
RefSeq | WP_006486849.1 |
GI | 206561279 |
Entrez | 6932891 |
GI | 206561279 |
INSDC | CAR53245.1 |
NCBI Locus Tag | QU43_RS51365 |
NCBI Old Locus Tag | BCAL2944 |
RefSeq | WP_006486849.1,GeneID |
UniParc | UPI00017B9731 |
UniProtKB Acc | B4EB34 |
UniProtKB ID | HLDD_BURCJ |
UniRef100 | UniRef100_B4EB34 |
UniRef50 | UniRef50_Q9HYQ8 |
UniRef90 | UniRef90_P0DMK5 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
ADP-l-glycero-D-manno-heptose-6-epimerase
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -2.16 |
Kyte-Doolittle Hydrophobicity Value | -0.301 |
Molecular Weight (kDa) | 37218.7 |
Isoelectric Point (pI) | 6.16 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
4EJ0 | ISOMERASE | 04/06/12 | Crystal structure of ADP-L-glycero-D-manno-heptose-6-epimerase from Burkholderia thailandensis | BURKHOLDERIA THAILANDENSIS | 2.609 | X-RAY DIFFRACTION | 93.2 |
Source 1 | |
Database | BGD |
Category | Lipopolysaccharide core region |
Evidence |
ECO:0000316
genetic interaction evidence used in manual assertion
|
Host Organism | Rattus norvegicus |
Notes | hldA-/hdlD- mutant does not survive in the rat agar bead model of chronic lung infection |
Reference | 16513737 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 599 genera
|
Burkholderia Ortholog Group |
BG000895 (654 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BCAL2944
Search term: hldD
Search term: ADP-l-glycero-D-manno-heptose-6-epimerase
|
A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo.
Loutet SA, Flannagan RS, Kooi C, Sokol PA, Valvano MA
J Bacteriol 2006 Mar;188(6):2073-80
PubMed ID: 16513737
|