Burkholderia cenocepacia J2315, BCAL0147 (metF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00676
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006555 methionine metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02219
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009086 methionine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00676
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0005829 cytosol
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00676
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0055114 oxidation-reduction process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00676
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
KEGG (InterPro) 00670 One carbon pool by folate InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bcj01120 Microbial metabolism in diverse environments 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc folate transformations II InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG (InterPro) 00720 Carbon fixation pathways in prokaryotes InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bcj01100 Metabolic pathways 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01200 Carbon metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc folate transformations I InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bcj00670 One carbon pool by folate 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
CDD cd00537 MTHFR IPR003171 Methylenetetrahydrofolate reductase 6 274 1.42398E-133
Gene3D G3DSA:3.20.20.220 1 276 9.4E-103
Pfam PF02219 Methylenetetrahydrofolate reductase IPR003171 Methylenetetrahydrofolate reductase 4 274 4.1E-93
SUPERFAMILY SSF51730 IPR029041 FAD-linked oxidoreductase-like 5 274 3.14E-100
TIGRFAM TIGR00676 fadh2: methylenetetrahydrofolate reductase [NAD(P)H] IPR004620 5,10-methylenetetrahydrofolate reductase 6 274 1.8E-102

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.