Burkholderia ambifaria AMMD, BAMB_RS28750 (hmqF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia ambifaria AMMD - Assembly GCF_000203915.1
GCF_000203915.1|latest
Locus Tag
BAMB_RS28750
NCBI Old Locus TagBamb_5768
Name
hmqF
Replicon chromosome 3
Genomic location 232857 - 236675 (+ strand)
CommentBelongs to the HMAQ biosynthesis operon hmqABCDEFG

Cross-References

RefSeq WP_041491757.1
GI 753123286
NCBI Locus Tag BAMB_RS28750
NCBI Old Locus Tag Bamb_5768
RefSeq WP_041491757.1

Product

Feature Type CDS
Coding Frame NA
Product Name
AMP-dependent synthetase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -16.95
Kyte-Doolittle Hydrophobicity Value -0.045
Molecular Weight (kDa) 137744.2
Isoelectric Point (pI) 6.05

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG017410 (460 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BAMB_RS28750
Search term: hmqF

Human Homologs

Ensembl 97, assembly GRCh38.p12
disco interacting protein 2 homolog A [Source:HGNC Symbol;Acc:HGNC:17217]
E-value: 1.4e-38
Percent Identity: 28.0
Ensembl 97, assembly GRCh38.p12
disco interacting protein 2 homolog A [Source:HGNC Symbol;Acc:HGNC:17217]
E-value: 1.4e-38
Percent Identity: 28.0

References

Burkholderia pseudomallei, B. thailandensis, and B. ambifaria produce 4-hydroxy-2-alkylquinoline analogues with a methyl group at the 3 position that is required for quorum-sensing regulation.
Vial L, Lépine F, Milot S, Groleau MC, Dekimpe V, Woods DE, Déziel E
J Bacteriol 2008 Aug;190(15):5339-52
PubMed ID: 18539738
Interplay between 4-Hydroxy-3-Methyl-2-Alkylquinoline and <i>N</i>-Acyl-Homoserine Lactone Signaling in a <i>Burkholderia cepacia</i> Complex Clinical Strain.
Chapalain A, Groleau MC, Le Guillouzer S, Miomandre A, Vial L, Milot S, Déziel E
Front Microbiol 2017;8:1021
PubMed ID: 28676791